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Obesity and Insulin Resistance: A Review of Molecular Interactions

[ Vol. 21 , Issue. 3 ]


Habib Yaribeygi *, Mina Maleki , Thozhukat Sathyapalan , Tannaz Jamialahmadi and Amirhossein Sahebkar *   Pages 182 - 193 ( 12 )


The prevalence of insulin resistance and diabetes mellitus is rising globally in epidemic proportions. Diabetes and its complications contribute to significant morbidity and mortality. An increase in sedentary lifestyle and consumption of a more energydense diet increased the incidence of obesity which is a significant risk factor for type 2 diabetes. Obesity acts as a potent upstream event that promotes molecular mechanisms involved in insulin resistance and diabetes mellitus. However, the exact molecular mechanisms between obesity and diabetes are not clearly understood. In the current study, we have reviewed the molecular interactions between obesity and type 2 diabetes.


Diabetes mellitus, obesity, oxidative stress, adipokine, adiponectin, adipocyte, Glut-4, insulin signal transduction.


Research Center of Physiology, Semnan University of Medical Sciences, Semnan, Chronic Kidney Disease Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Academic Diabetes, Endocrinology and Metabolism, Hull York Medical School, University of Hull, Department of Food Science and Technology, Quchan Branch, Islamic Azad University, Quchan, Halal Research Center of IRI, FDA, Tehran

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