Mentor Sopjani*, Rifat Morina, Valdet Uka, Nguyen Thi Xuan and Miribane Dërmaku-Sopjani* Pages 417 - 425 ( 9 )
Janus kinase-2 (JAK2) is a non-receptor tyrosine kinase that serves key roles as the intracellular signaling effector of the cytokine receptor, such as mediating effects of leptin, erythropoietin, interferon, and growth hormone. A lot of molecular underlying mechanisms of JAK2 participation are known, however, additional signaling mechanisms of its activation, regulation, and pleiotropic signaling roles are still being explored. Here, we review the current knowledge of JAK2-mediated cellular signaling at the molecular level. In the beginning, we will focus on the recent advances in JAK2 activation and regulation. A part of our review focuses on the JAK2 involvement in various diseases/conditions. Recent advances highlight the molecular regulatory mechanisms utilized by the JAK2 signaling, thus, enabling to consider alternative therapeutic strategies to treat various diseases/conditions mediated by JAK2 by using it as a therapeutic target.
Jak2, STAT, protein kinases, hormones, intracellular signaling, cytokine receptor.
Faculty of Medicine, University of Prishtina, 10 000, Prishtine, Faculty of Education, University of Prizren, 20 000, Prizren, Faculty of Medicine, University of Prishtina, 10 000, Prishtine, Institute of Genome Research, Vietnam Academy of Science and Technology, 18 Hoang Quoc Viet, Cau Giay, Hanoi, Faculty of Natural Sciences and Mathematics, University of Prishtina, 10 000, Prishtinë