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Profilin1 Sensitizes Pancreatic Cancer Cells to Irradiation by Inducing Apoptosis and Reducing Autophagy

[ Vol. 13 , Issue. 8 ]

Author(s):

H. Cheng, J. Li, C. Liu, W. Yao, Y. Xu, T. S. Frank, X. Cai, S. Shi, Y. Lu, Y. Qin, L. Liu, J. Xu, J. Long, Q.-X. Ni, M. Li and X.-J. Yu   Pages 1368 - 1375 ( 8 )

Abstract:


Pancreatic cancer has an extremely poor prognosis mainly due to lack of effective treatment options. Radiotherapy is mostly applied to locally advanced cases, although tumor radioresistance limits the effectiveness. Profilin1, a novel tumor suppressor gene, was reported to be down-regulated in various cancers and associated with tumor progression. The objective of this study was to demonstrate how profilin1 affected pancreatic cancer radiosensitivity. We showed profilin1 was down-regulated in pancreatic cancer cells after exposure to radiation, and re-expression of profilin1 suppressed tumor cell viability and increased DNA damage following irradiation. Further studies revealed that up-regulation of profilin1 facilitated apoptosis and repressed autophagy induced by irradiation, which might sensitize pancreatic cancer cells to radiation treatment. Our findings may provide a novel therapeutic strategy for sensitizing pancreatic cancer to radiotherapy.

Keywords:

Apoptosis, autophagy, DNA damage, pancreatic cancer, profilin1, radiation.

Affiliation:

(X.-J. Yu) Pancreatic Cancer Institute, Fudan University; Department of Pancreatic & Hepatobiliary Surgery, Fudan University Shanghai Cancer Center, 270 DongAn Road, Shanghai 200032, P. R. China.



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