Monika Pahuja *, Jogender Mehla and Yogendra Kumar Gupta Pages 1 - 18 ( 18 )
Background: Use of plants and plant products in health care has shown exponential increase in past two decades. <P> Introduction: In-spite of the availability of well-established pharmacotherapy for epilepsy, a large no of population still explores alternative treatments due to refractory seizures, adverse effects of drugs, chronic treatment, inaccessibility of standard therapies in rural areas and the social stigma attached to the disease. Various studies on medicinal plants showed the protective effect of herbals in animal models of epilepsy. <P> Method: In the present review, a status analysis of the traditional use of various medicinal plants in epilepsy with a special focus on plats having anti-inflammatory potential is recorded. <P> Result and Conclusion: The shortcomings of research on medicinal plants which needs to be explored further in order to tackle the growing need of safer and effective drugs for epilepsy are discussed. Overall, there is a huge scope of herbal drugs in CNS disorders especially epilepsy, either as an adjunct by reducing the dose and thus side effects of standard anti-epileptic drugs or as standalone agent . Although, there is still an urgent need of well planned randomized controlled clinical trials to validate their efficacy and safety.
epilepsy, herbal drugs, CNS activity, herb-drug interaction
Division of Basic Medical Sciences, Indian Council of Medical Research, New Delhi – 110 029, Department of Neurological Surgery, Washington University School of Medicine, St. Louis-63110, Missouri, Department of Pharmacology, All India Institute of Medical Sciences, New Delhi – 110 029