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Nutrigenomics and Lifestyle Facet- A Modulatory Molecular Evidence in Progression of Breast and Colon Cancer with Emerging Importance

[ Vol. 22 , Issue. 4 ]


Suman Kumar Ray and Sukhes Mukherjee*   Pages 336 - 348 ( 13 )


Legitimate nutrition assumes a significant role in preventing diseases and, in this way, nutritional interventions establish vital strategies in the area of public health. Nutrigenomics centres on the different genes and diets in an individual and how an individual’s genes influence the reaction to bioactive foodstuff. It targets considering the genetic and epigenetic interactions with nutrients to lead to a phenotypic alteration and consequently to metabolism, differentiation, or even apoptosis. Nutrigenomics and lifestyle factors play a vital role in health management and represent an exceptional prospect for the improvement of personalized diets to the individual at risk of developing diseases like cancer. Concerning cancer as a multifactorial genetic ailment, several aspects need to be investigated and analysed. Various perspectives should be researched and examined regarding the development and prognosis of breast and colon cancer. Malignant growth occurrence is anticipated to upsurge in the impending days, and an effective anticipatory strategy is required. The effect of dietary components, basically studied by nutrigenomics, looks at gene expression and molecular mechanisms. It also interrelates bioactive compounds and nutrients because of different 'omics' innovations. Several preclinical investigations demonstrate the pertinent role of nutrigenomics in breast and colon cancer, and change of dietary propensities is conceivably a successful methodology for reducing cancer risk. With the connection between the genomic profile of patients with breast or colon cancer and their supplement intake, it is conceivable to imagine an idea of personalized medicine, including nutrition and medicinal services.


Nutrigenomics, nutritional interventions, lifestyle factors, breast and colon cancer, dietary propensities, molecular mechanisms, personalized nutrition.


Independent researcher, Department of Biochemistry. All India Institute of Medical Sciences. Bhopal, Madhya Pradesh-462020

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