Afsane Bahrami * and Gordon A. Ferns Pages 860 - 869 ( 10 )
MicroRNAs (miRs) is a class of conserved, small, noncoding RNA molecules that modulate gene expression post-transcriptionally. miR-148b is a member of miR- 148/152 family generally known to be a tumor suppressor via its effect on different signaling pathways and regulatory genes. Aberrant expression of miR-148b has recently been shown to be responsible for tumorigenesis of several different cancer types. This review discusses the current evidence regarding the involvement of miR-148b expression in human cancers and its potential clinical importance for tumor diagnosis, prognosis, and therapeutics.
miR-148/152, KIT, Cyclin D1, ALCAM, WNT, cancer.
Cellular and Molecular Research Center, Birjand University of Medical Sciences, Birjand, Division of Medical Education, Brighton & Sussex Medical School, Brighton, Sussex