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The Role of Bone Morphogenetic Protein 4 in Lung Diseases

[ Vol. 23 , Issue. 4 ]


Xiaoxiao Dong, Yimin Mao* and Pengfei Gao*   Pages 324 - 331 ( 8 )


Bone morphogenetic protein 4 (BMP4) is a multifunctional secretory protein that belongs to the transforming growth factor β superfamily. BMPs transduce their signaling to the cytoplasm by binding to membrane receptors of the serine/threonine kinase family, including BMP type I and type II receptors. BMP4 participates in various biological processes, such as embryonic development, epithelial-mesenchymal transition, and maintenance of tissue homeostasis. The interaction between BMP4 and the corresponding endogenous antagonists plays a key role in the precise regulation of BMP4 signaling. In this paper, we review the pathogenesis of BMP4-related lung diseases and the foundation on which BMP4 endogenous antagonists have been developed as potential targets.


Bone morphogenetic protein 4, congenital pulmonary airway malformation, pulmonary artery hypertension, pulmonary fibrosis, asthma, chronic obstructive pulmonary disease, non-small cell lung cancer, endogenous antagonists.


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