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The Importance of mir-491-5p in Various Cancers

[ Vol. 23 , Issue. 9 ]


Mahsa Fakeri, Seyed Masoud Armandzadeh, Samad Sadigh Olyaei, Zahra Foruzandeh and Mohammad Reza Alivand*   Pages 921 - 933 ( 13 )


MicroRNAs are non-coding ribonucleic acids that are evolutionarily protected. MiRNAs control the expression of genes after transcription by mRNA decomposition or the inhibition of their translation. These molecular structures control physiological and pathological processes; therefore, many of them can play vital roles as oncogenes or tumor inhibitors. Besides, the occurrence of various mutations in miRNAs can lead to cancer. In this review article, we want to peruse the role of miR-491-5p in various cancers. In recent years, many experiments and studies have been performed on the involvement of miR-491-5p in cancer, invasion, and cell metastasis. Metastasis is an event that makes cancer more advanced and harder to treat. When cancer is invasive, the cancer cells invade nearby tissues or other organs and develop cancer. Tumor studies have shown that miR-491-5p can inhibit cell growth, invasion, and metastasis. Thus, expression enhancement of miR-491-5p disrupts cell migration and improves cancer.


Non-coding RNAs, microRNAs, cancer, Mir-491-5p, transcriptional gene regulation, mRNA decomposition.


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