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Genetic Aspects of Glaucoma: An Updated Review


Oscar Francisco Chacon-Camacho, Rocio Arce-Gonzalez, Fernanda Sanchez-de la Rosa, Andrés Urióstegui-Rojas, María Enriqueta Hofmann-Blancas, Felipe Mata-Flores and Juan Carlos Zenteno*   Pages 1 - 19 ( 19 )


Glaucoma is a group of diverse diseases characterized by cupping of the optic nerve head due to the loss of retinal ganglion cells. It is the most common cause of irreversible blindness throughout the world; therefore, its timely diagnosis and early detection through an ophthalmological examination are very important. We, herein, present the information on the epidemiology, pathophysiology, clinical diagnosis, and treatment of glaucoma. We also emphasize the investigations of the last decades that have allowed identifying numerous genes and susceptibility genetic factors. We have also described in detail the genes whose mutations cause or contribute to the development of the disease.


glaucoma,glaucoma genetics,monogenetic glaucoma,glaucoma genes,blindness,NGS,microarrays,elevated intraocular pressure glaucoma,elevated intraocular pressure


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