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Oncogenic Alterations of Metabolism Associated with Resistance to Chemotherapy

[ Vol. 24 , Issue. 7 ]


Fahimeh Ghasemi, Tahereh Farkhondeh, Saeed Samarghandian, Alireza Ghasempour and Mehdi Shakibaie*   Pages 856 - 866 ( 11 )


Metabolic reprogramming in cancer cells is a strategy to meet high proliferation rates, invasion, and metastasis. Also, several researchers indicated that the cellular metabolism changed during the resistance to chemotherapy. Since glycolytic enzymes play a prominent role in these alterations, the ability to reduce resistance to chemotherapy drugs is promising for cancer patients. Oscillating gene expression of these enzymes was involved in the proliferation, invasion, and metastasis of cancer cells. This review discussed the roles of some glycolytic enzymes associated with cancer progression and resistance to chemotherapy in the various cancer types.


Chemotherapy resistance, hexokinase, phosphofructokinase, phosphoglycerate kinase, aldolase, glyceraldehyde 3-phosphate dehydrogenase, enolase, pyruvate kinase, lactate dehydrogenase.


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