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Polypyrimidine Tract Binding Protein: A Universal Player in Cancer Development


Elizabeth Gonzalez, Terrie G Flatt, Midhat Farooqi, Lisa Johnson and Atif A. Ahmed*   Pages 1 - 11 ( 11 )


Objectives: Polypyrimidine tract binding protein is a 57-Kda protein located in the perinucleolar compartment where it binds RNA and regulates several biological functions through the regulation of RNA splicing. Numerous research articles have been published that address the cellular network and functions of PTB and its isoforms in various disease states. <P> </P> Methodology: Through an extensive PubMed search, we attempt to summarize the relevant research into this biomolecule. <P> </P> Results: Besides its roles in embryonic development, neuronal cell growth, RNA metabolism, apoptosis, and hematopoiesis, PTB can affect cancer growth via several metabolic, proliferative, and structural mechanisms. PTB overexpression has been documented in several cancers where it plays a role as a novel prognostic factor. <P> </P> Conclusion: The diverse carcinogenic effect opens an argument into its potential role in inhibitory targeted therapy.


Polypyrimidine tract binding protein,PNC,RNA splicing,cancer


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