Submit Manuscript  

Article Details


The Roles of the Unique Prolyl Isomerase Pin1 in Cancer-Related Viral and Bacterial Infections

[ Vol. 16 , Issue. 9 ]

Author(s):

J. Wang, X.-H. Liao, M. Zheng, D. Yang, X. Z. Zhou, H. Liu and K. P. Lu   Pages 793 - 802 ( 10 )

Abstract:


Infection is the process of pathogen invasion, as well as the host reaction to the foreign agents. Proline-directed phosphorylation is a major regulatory mechanism that regulates the function of fundamental proteins involved in infection and infection-induced cancer. Recently, the identification of the phosphorylation-dependent prolyl isomerase Pin1 has uncovered a unique regulatory signaling mechanism controlling protein conformation and function after phosphorylation. Pin1 is the only proline isomerase that specifically recognizes certain Pro-directed Ser/Thr phosphorylation motifs. Pin1 has emerged as a major regulator of cancerrelated viral and bacterial infections notably via activating Toll-like receptor signaling and NF-κB pathways. This paper will specifically review recent findings on the role of Pin1 in cancer-related viral and bacterial infections and also discuss newly discovered Pin1 inhibitors as promising drugs for the prevention and treatment of viral and bacterial infections and associated tumorigenesis.

Keywords:

Prolyl isomerase Pin1, cancer-related viral and bacterial infections, ATRA, inflammatory response, NF- κB, Toll-like receptors.

Affiliation:

Fujian Key Laboratory for Translational Research in Cancer and Neurodegenerative Diseases, Institute for Translational Medicine, Fujian Medical University, Fuzhou, Fujian 350108, China.



Read Full-Text article