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Sumoylation in Lens Differentiation and Pathogenesis

[ Vol. 16 , Issue. 10 ]

Author(s):

J.-W. Xiang, Z.-G. Chen, L. Gong, Y. Xiao, W.-J. Qing, L. Wang, X.-H. Hu, Z.-X. Huang, R.-L. Qi, T.-H. Yang, A.-P. Arrigo, L. Zhang, X.-C. Tang, S. Huang, F.-Y. Liu, Z.-W. Luo, Y.-F. Liu, Q. Sun, J. Gigantelli, Y.-Z. Liu and D. W.-C. Li   Pages 859 - 870 ( 12 )

Abstract:


Sumoylation, a post-translational modification discovered over a decade ago, turns out to be a very important regulatory mechanism mediating multiple cellular processes. Recent studies from our laboratory and others also revealed that it plays a crucial role in regulating both differentiation and pathogenesis of the ocular lens. This review will summarize these progresses.

Keywords:

Lens, sumoylation, differentiation, cataractogenesis, pathogenesis.

Affiliation:

Key Laboratory of Protein Chemistry and Developmental Biology of Educational Ministry of China, College of Life Sciences, Hunan Normal University, Changsha, Hunan 410081



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