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Liposomes as a Promising Ultrasound-Triggered Drug Delivery System in Cancer Treatment

[ Vol. 17 , Issue. 10 ]

Author(s):

N.M. Salkho, R.Z. Turki, O. Guessoum, A.M. Martins, R.F. Vitor and G.A. Husseini*   Pages 668 - 688 ( 21 )

Abstract:


The initial uses of ultrasound waves in the medical field were limited to the thermal ablation of solid tumors and as a diagnostic tool. Recent advances at the preclinical stage have allowed the use of ultrasound as a powerful tool to improve drug delivery when the agent is administered encapsulated inside a nanoparticle. This spatial and temporal control of drug release, using a non-invasive modality, is a promising approach to decrease the side effects of conventional chemotherapy in cancer treatments, as it reduces the interaction of the anti-neoplastic agent with healthy tissues.

In this review, we explain the physics of ultrasound, introduce and discuss several examples on the use of nanoparticles as drug carriers, with a focus on liposomes. Examples of in vitro and in vivo studies are presented and discussed.

Keywords:

Cancer, liposomes, drug delivery, ultrasound, drug release, anti-neoplastic agent.

Affiliation:

Department of Chemical Engineering, American University of Sharjah, Sharjah, Department of Chemical Engineering, American University of Sharjah, Sharjah, Department of Chemistry, Biology and Environmental Science, American University of Sharjah, Sharjah, Department of Chemical Engineering, American University of Sharjah, Sharjah, Department of Chemical Engineering, American University of Sharjah, Sharjah, Department of Chemical Engineering, American University of Sharjah, Sharjah



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