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The Effect of Interleukin 38 on Inflammation-induced Corneal Neovascularization

[ Vol. 19 , Issue. 8 ]

Author(s):

Jiangli Zhu, Jing Zhang, Yan Wang, Jianping Chen, Xiaopeng Li, Xiangling Liu, Eryan Kong, Shao B. Su* and Zhongjian Zhang*   Pages 589 - 596 ( 8 )

Abstract:


Background: Angiogenesis is tightly linked to inflammation. Cytokines of interleukin 1 (IL-1) family are key mediators in modulating inflammatory responses.

Methods: In this study, we examined the role of IL-38, a member of the IL-1 family, in mediating inflammation-induced angiogenesis.

Results: The results showed that the angiogenesis was attenuated by topical administration of IL-38 to the injured corneas in a mouse model of alkali-induced corneal neovascularization (CNV). Further study showed that the expression of inflammatory cytokines TNF-α, IL-6, IL-8 and IL-1β was decreased in the IL-38-treated corneas. Moreover, the angiogenic activities including the proliferation, migration and tube formation of human retinal endothelial cells were reduced by IL-38 treatment in vitro.

Conclusion: The data indicate that IL-38 modulates inflammation-induced angiogenesis.

Keywords:

Angiogenesis, cytokine, interleukin, inflammation, IL-38, neovascularization.

Affiliation:

The Third Affiliated Hospital of Xinxiang Medical University, Xinxiang, Henan, 453000, State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, 510060, Guangdong Science and Technology Library (Guangdong Institute of Scientific and Technical Information and Development Strategy), State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, 510060, The Third Affiliated Hospital of Xinxiang Medical University, Xinxiang, Henan, 453000, The Third Affiliated Hospital of Xinxiang Medical University, Xinxiang, Henan, 453000, Institute of Psychiatry and Neuroscience, Xinxiang Medical University, Xinxiang, Henan, 453000, The Third Affiliated Hospital of Xinxiang Medical University, Xinxiang, Henan, 453000, Institute of Psychiatry and Neuroscience, Xinxiang Medical University, Xinxiang, Henan, 453000



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