Submit Manuscript  

Article Details


The Effects of Cholesterol Metabolism on Follicular Development and Ovarian Function

[ Vol. 19 , Issue. 10 ]

Author(s):

Qin Huang, Yannan Liu, Zhen Yang, Yuanjie Xie and Zhongcheng Mo*   Pages 719 - 730 ( 12 )

Abstract:


Cholesterol is an important substrate for the synthesis of ovarian sex hormones and has an important influence on follicular development. The cholesterol in follicular fluid is mainly derived from plasma. High-density lipoprotein (HDL) and lowdensity lipoprotein (LDL) play important roles in ovarian cholesterol transport. The knockout of related receptors in the mammalian HDL and LDL pathways results in the reduction or absence of fertility, leading us to support the importance of cholesterol homeostasis in the ovary. However, little is known about ovarian cholesterol metabolism and the complex regulation of its homeostasis. Here, we reviewed the cholesterol metabolism in the ovary and speculated that regardless of the functioning of cholesterol metabolism in the system or the ovarian microenvironment, an imbalance in cholesterol homeostasis is likely to have an adverse effect on ovarian structure and function.

Keywords:

Ovarian follicles, lipoprotein, sterol carrier protein 2, steroidogenesis, cholesterol homeostasis, fertility.

Affiliation:

Clinical Anatomy & Reproductive Medicine Application Institute, Department of Histology and Embryology, Hengyang Medical school, University of South China, Hengyang 421001, Nursing School, Hunan University of Medicine, Huaihua 418000, Clinical Anatomy & Reproductive Medicine Application Institute, Department of Histology and Embryology, Hengyang Medical school, University of South China, Hengyang 421001, Clinical Anatomy & Reproductive Medicine Application Institute, Department of Histology and Embryology, Hengyang Medical school, University of South China, Hengyang 421001, Clinical Anatomy & Reproductive Medicine Application Institute, Department of Histology and Embryology, Hengyang Medical school, University of South China, Hengyang 421001



Read Full-Text article