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Circular RNA and Diabetes: Epigenetic Regulator with Diagnostic Role

Author(s):

Kazem Abbaszadeh-Goudarzi, Shabnam Radbakhsh, Mohammad Hossein Pourhanifeh, Hashem Khanbabaei, Amirhosein Davoodvandi, Hadis Fathizadeh, Amirhossein Sahebkar, Mohammad Karim Shahrzad and Hamed Mirzaei*   Pages 1 - 11 ( 11 )

Abstract:


Circular RNAs, a group of endogenous non-coding RNAs, are characterized by covalently closed cyclic structures with no poly-adenylated tails. It has been recently recommended that cirRNAs have an essential role in regulating genes expression by functioning as a translational regulator, RNA binding protein sponge and microRNA sponge. Due to their close relation to the progression of various diseases such as diabetes, circRNAs have become a research hotspot. A number of circRNAs (i.e., circRNA_0054633, circHIPK3, circANKRD36, and circRNA11783-2) have been shown to be associated with initiation and progression of diabetes. Based on reports, in a tissue, some circRNAs are expressed in a developmental stage-specific manner. In this study, we reviewed research on circular RNAs involved in the pathogenesis and diagnosis of diabetes and their prognostic roles.

Keywords:

Circular RNA, Diabetes, Biomarker, circRNA_0054633, circHIPK3, circANKRD36

Affiliation:

Cellular and Molecular Research Center, Department of Biochemistry and Nutrition, Sabzevar University of Medical Sciences, Sabzevar, Department of Medical Biotechnology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Student Research Committee, Mashhad University of Medical Sciences, Mashhad, Halal Research Center of IRI, FDA, Tehran, Student Research Committee, Mashhad University of Medical Sciences, Mashhad, Division of General Internal Medicine, Toronto General Hospital, Toronto, Radiobiology Laboratory, Medical Physics Department, School of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Research Center for Biochemistry and Nutrition in Metabolic Diseases, Institute for Basic Sciences, Kashan University of Medical Sciences, Kashan, I.R. , Student Research Committee, Mashhad University of Medical Sciences, Mashhad



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