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Cholesterol: A Prelate in Cell Nucleus and its Serendipity

Author(s):

Nimisha Saxena and Nimai Chand Chandra*   Pages 1 - 16 ( 16 )

Abstract:


Cholesterol is a chameleon bio-molecule in cellular multiplex. It acts as a prelate in almost every cellular compartment with its site specific characteristics viz. regulation of structural veracity and scaffold fluidity of bio-membranes, insulation of electrical transmission in nerves, controlling of genes by making steroid endocrines, acting as precursors of metabolic regulators and many more with its emerging prophecy in cell nucleus to drive new cell formation. Besides the crucial legacy in cellular functionality, cholesterol is ostracized as a member of LDL particle which has been proved responsible to clog blood vessels. LDL particles get deposited in the blood vessels because of its poor clearance owing to the non-functioning LDL receptor on vessel wall and surrounding tissues. Blocking of blood vessel promotes heart attack and stroke. On the other hand cholesterol has been targeted as pro-cancerous molecule. At this phase again cholesterol is biphasic. Although cholesterol is essential to construct nuclear membrane and its lipid-rafts; in cancer tumour cells cholesterol is not under control of intracellular feedback regulation and gets accumulated within cell nucleus by crossing nuclear membrane and promotes cell proliferation. In precancerous stage the immune cells also die because of lack of requisite concentration of intracellular and intranuclear cholesterol pool. Existence of cholesterol within the cell nucleus has been found in nuclear membrane, epichromosomal location and nucleoplasm. The existence of cholesterol in the microdomain of nuclear raft has been reported to be linked with gene transcription, cell proliferation and apoptosis. Hydrolysis of cholesterol esters in chromosomal domain is linked with new cell generation. Apparently Cholesterol is now a prelate in cell nucleus too ------ A serendipity in cellular haven.

Keywords:

cholesterol, microdomain, nuclear raft , cell proliferation, nucleoplasm, nucleus

Affiliation:

Department of Biochemistry, KDMCH & Research Center, Akbarpur, Mathura - 281406, Department of Biochemistry, All India Institute of Medical Sciences, Phulwarisharif, Patna – 801507



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