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Cartilage Tissue and Therapeutic Strategies for Cartilage Repair

Author(s):

Sahar Khajeh, Farzaneh Bozorg-Ghalati, Mina Zare, Ghodratollah Panahi and Vahid Razban*   Pages 1 - 17 ( 17 )

Abstract:


High incidence of articular cartilage defects is still a major challenge in orthopedic and trauma surgery worldwide. It has also great socioeconomic effects as it is the major cause of disability in industrialized countries. These highlight the essential need for new treatments. Knowledge about the factors that have been implicated in the pathogenesis of cartilage diseases, including changes in the composition and structure of cartilaginous extracellular matrix (ECM), molecular factors and environmental signaling pathways could help the development of innovative therapeutic strategies. It is consensuses that the success of any technology aiming to repair chondral defects will be dependent upon its ability to produce tissues that most closely replicate the mechanical and biochemical properties of native cartilage. Increasing our knowledge about cartilage tissue and its molecular biomarkers could help us to find new and useful therapeutic approach in cartilage damage. This review tries to describe cartilage tissue biology in detail and discuss different available therapeutic modalities with their pros and cons. New cartilage regeneration strategies and therapies, with focusing on cell-based therapy and tissue engineering, and their underlying molecular and cellular bases will be pointed out as well.

Keywords:

Articular cartilage, stem cell therapy, autologous chondrocyte implantation, tissue engineering.

Affiliation:

Department of Biochemistry, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Department of Molecular Medicine, School of Advanced Medical Sciences and Technologies, Shiraz University of Medical Sciences, Shiraz, Department of Biochemistry, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Department of Biochemistry, Faculty of Medicine, Tehran University of Medical sciences, Tehran, Department of Molecular Medicine, School of Advanced Medical Sciences and Technologies, Shiraz University of Medical Sciences, Shiraz



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