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Vitamin D and Non-coding RNAs: New Insights into the Regulation of Breast Cancer

[ Vol. 21 , Issue. 3 ]

Author(s):

Mohammad Karim Shahrzad, Reyhaneh Gharehgozlou, Sara Fadaei, Parastoo Hajian and Hamid Reza Mirzaei*   Pages 194 - 210 ( 17 )

Abstract:


Breast cancer, a life-threatening serious disease with a high incident rate among women, is responsible for thousands of cancer-associated death worldwide. Numerous investigations have evaluated the possible mechanisms related to this malignancy. Among them, non-coding RNAs (ncRNAs), i.e., microRNAs (miRNAs), long non-coding RNAs (lncRNAs), and circular RNAs have recently attracted attention of researchers. In addition to recent studies for evaluating the role of ncRNAs in breast cancer etiology, some investigations have revealed that vitamin D has regulatory and therapeutic roles in breast cancer. Moreover, an important link between vitamin D and ncRNAs in cancer therapy has been highlighted. Herein, the aim of this study was to discuss the available data on the mentioned link in breast cancer.

Keywords:

Breast cancer, vitamin D, long non-coding RNAs, microRNAs, non-coding RNAs, malignancy.

Affiliation:

Department of Internal Medicine and endocrinology, Shohadae Tajrish Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Cancer Research Center, Shohada Tajrish Hospital, Department of Radiation Oncology, Shahid Beheshti University of Medical Sciences, Tehran, Department of Internal Medicine and endocrinology, Beheshti University of Medical Sciences, Tehran, Cancer Research Center, Shohada Tajrish Hospital, Department of Radiation Oncology, Shahid Beheshti University of Medical Sciences, Tehran, Cancer Research Center, Shohada Tajrish Hospital, Department of Radiation Oncology, Shahid Beheshti University of Medical Sciences, Tehran



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