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Bacteriocins: New Potential Therapeutic Candidates in Cancer Therapy

Author(s):

Hadis Fathizadeh*, Mahmood Saffari, Davoud Esmaeili, Rezvan Moniri and Hossein Samadi Kafil   Pages 1 - 10 ( 10 )

Abstract:


Cancer is one of the most important disorders which is associated with high mortality and high costs of treatment for patients. Despite several efforts, finding, designing and developing, new therapeutic platforms in treatment of cancer patients are still required. Utilization of microorganisms particularly bacteria has emerged as new therapeutic approaches in the treatment of various cancers. Increasing data indicated that bacteria could be used in the production of a wide range of anti-cancer agents including bacteriocins, antibiotics, peptides, enzymes, and toxins. Among these anti-cancer agents, bacteriocins have attractive properties which make them as powerful anti-cancer drugs. Multiple lines evidence indicated that several bacteriocins (i.e. colcins, nisins, pediocins, pyocins, and bovocins) via activation/inhibition different cellular and molecular signaling pathways are able to suppress tumor growth in various stages. Hence, identification and using various bacteriocins could lead to improve and introduce them to clinical practices. Here, we summarized various bacteriocins which could be employed as anti-cancer agents in the treatment of many cancers.

Keywords:

Bacteriocins, Cancer, Therapy, Tumor; bacteria; anticancer agent

Affiliation:

Department of Microbiology and immunology, Kashan University of Medical Sciences, Kashan, I.R., Department of Microbiology and immunology, Kashan University of Medical Sciences, Kashan, I.R., Department of Microbiology and Applied Microbiology Research Center, Systems biology and poisonings institute, Baqiyatallah University of Medical sciences, Tehran, Department of Microbiology and immunology, Kashan University of Medical Sciences, Kashan, I.R., Department of Bacteriology and Virology, School of Medicine, Tabriz University of Medical Sciences, IR



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