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Study Aging by Fibroblasts Metabolome

Author(s):

Ana Rocha, Sandra Magalhães and Alexandra Nunes*   Pages 1 - 18 ( 18 )

Abstract:


Aging is a complex multifactorial process that although universal is not fully understood. It is known that the impact of aging on health is influenced by multiple factors, such as sex, race, income, and education, and that age-related dis-eases are strongly associated to the way people get old. The knowledge of biological aging and its comparison to the chronological age is a paramount contributor to predict the metabolic decline and the onset of age-related diseases.

As aging processes observed in whole human organism are somehow the reflexion of what happens in each cell type, it is possible to study aging process using cell lines, such as fibroblasts.

Metabolomics analysis of cell lines, namely fibroblasts, gives inputs to personalized or integrative medicine; in fact cell metabolomics is an emerging field that addresses fundamental biological and metabolic questions using modern "omic" techniques as FTIR, NMR or MS.

This paper revises the relevance of using fibroblasts as cell models to study the metabolome of aging.

Keywords:

Aging, Fibrobalsts, Metabolome, FTIR, MS, NMR

Affiliation:

iBiMED –Institute of Biomedicine, Department of Medical Sciences, University of Aveiro, Aveiro, iBiMED –Institute of Biomedicine, Department of Medical Sciences, University of Aveiro, Aveiro, iBiMED –Institute of Biomedicine, Department of Medical Sciences, University of Aveiro, Aveiro



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