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CircRNAs in Lung-intestinal Axis Cancer

Author(s):

Chengmin Wang, Yuan Fen, Bingxin Li, Di Zhou, Jingjing Ma, Gang Chen* and Ning Li*   Pages 1 - 9 ( 9 )

Abstract:


The“exterior-interior relationship between the lung and the large intestine” is a basic theory in Traditional Chinese Medicine (TCM), which has been confirmed by mounting evidence, and the lung-intestinal axis can be seen as an ex-tension of this theory.Circular RNAs (circRNAs) are a kind of conserved and structurally stable non-coding RNAs, which have been found to be differentially expressed and associated with the development of cancer in malignant tumors.Many studies have found that circRNAs play an important role in the lung and intestinal cancers. This review focuses on circRNAs and reveals that there are common circRNAs that are both highly or poorly expressed in lung-intestinal axis cancers and most of them regulate the proliferation, migration,and invasion of cancer cells by sponging miRNAs. These results not only provide new evidences and research ideas for the “exterior-interior relationship between the lung and the large intestine”, but also suggests that circRNAs can be new potential therapeutic targets for the future drug research of lung-intestinal axis diseases.

Keywords:

circRNAs, lung-intestinal axis, miRNA, differential expression, lung-intestinal exterior-interior relationship, biomarker

Affiliation:

School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016,, School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016,, School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016,, School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016,, School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016,, School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016,, School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016



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