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Role of Oxidative Stress and Antioxidant Supplementation in Male Fertility


Zahra Beygi, Sedighe Forouhari, Elahe Mahmoudi, Seyed Mohammad Gheibi Hayat and Firoozeh Nourimand*   Pages 1 - 18 ( 18 )


Nearly 15% of couples involve in infertility as a universal health issue. About 50% of infertility cases have been known to be associated with the male parameters. Oxidative stress (OS) represents an imbalance in the level of reactive ox-ygen species (ROS) and anti-oxidant. In fact, OS has been considered as one of the popular pathologies reported in about 50% of all infertile male. Therefore, the increased level of ROS may result in infertility via DNA damages or lipid peroxida-tion (LPO) as well as the enzymes inactivation and proteins oxidation in spermatozoa. Basically, OS results from the life-style variables. As the absence of antioxidant and the respective deficiencies in the semen cause OS, variations in the life-style and anti-oxidant regimes may be advantageous to treatment strategies for resolving such an issue. Actually, anti-oxidants like vitamins E and C, glutathione, coenzyme-Q10, carnitines, selenium, N-acetylcysteine, carotenoids, zinc, and pentoxifylline decline the OS-induced sperm damages.Therefore, the present review overviews the oxidative bio-chemistry associated with the sperm health and identifies which men would be most at risk of the oxidative infertility. Hence, the re-view would show the techniques provided to diagnose OS and diverse therapeutic options.


Male infertility, Sperm, Oxidative stress, Antioxidant, Free radicals


Department of Midwifery, School of Nursing and Midwifery, Islamic azad University Meybod branch, Yazd, Infertility Research Center, Research center of Quran, Hadith and medicine, Shiraz University of Medical Sciences, Shiraz, Vali Asr Educational Hospital Arsanjan, University of Medical science's Shiraz, Genetic Depart-ment, Faculty of Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Vali Asr Educational Hospital, Fasa University of Medical Sciences, Fas

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