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Innate Immunity Alterations in Type 2 Diabetes Mellitus: Understanding Infection Susceptibility

Author(s):

Ochoa-González Fátima de Lourdes, González-Curiel Irma Elizabeth, Cervantes-Villagrana Alberto Rafael, Fernández-Ruiz Julio Cesar and Castañeda-Delgado Julio Enrique*   Pages 1 - 14 ( 14 )

Abstract:


Diabetes is a chronic disease characterized by marked alterations in the metabolism of glucose andby high con-centrations of glucose in the blood due to a decreased insulin production or resistance to the action of this hormone in pe-ripheral tissues. The International Diabetes Federation estimates a global incidence of diabetes of about 10% in the adult population (20 -79 years old), some 430 million cases reported worldwide in 2018. It is well documented that people with diabetes have a higher susceptibility to infectious diseases and therefore show higher morbidity and mortality compared to the non-diabetic population. Given that the innate immune response plays a fundamental role in protecting against invading pathogens through a myriad of humoral and cellular mechanisms, the present work makes a comprehensive review of the innate immune alterations in patients with type 2 diabetes mellitus (T2D) as well as a brief description of the molecular events leading or associated to such conditions.We show that in these patients a compromised innate immune response in-creases susceptibility to infections.

Keywords:

Innate response, phagocytosis, Type 2 Diabetes Mellitus, infection, antimicrobial peptide, innate immune cells

Affiliation:

Unidad de Investigación Biomédica de Zacatecas, Instituto Mexicano del Seguro Social (IMSS), Zacatecas, Zac, Universidad Autónoma deZacatecas, Unidad Académica de Ciencias Químicas, Maestría enCiencias y Tecnología Química,Zacatecas, Zac, Universidad Autónoma deZacatecas, Unidad Académica de Ciencias Químicas, Maestría enCiencias y Tecnología Química,Zacatecas, Zac, Unidad de Investigación Biomédica de Zacatecas, Instituto Mexicano del Seguro Social (IMSS), Zacatecas, Zac, Unidad de Investigación Biomédica de Zacatecas, Instituto Mexicano del Seguro Social (IMSS), Zacatecas, Zac



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