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Addressing the importance of Stem cell-based therapy: a Perspective in the treatment of COVID-19’

Author(s):

Christine Ibrahim, Hanna Semaan, Marwan El-Sabban*, Fadia Najjar* and Aline Hamade*   Pages 1 - 19 ( 19 )

Abstract:


Severe acute respiratory syndrome-associated corona virus 2 (SARS-CoV-2), is an extremely pathogenic virus belonging to the family of Coronaviridae. First identified in Wuhan China in December 2019 after an epidemiological investigation of an emerging cluster of pneumonia of unknown etiology, SARS-CoV-2 was declared the cause of a pandemic on March 11 by the World Health Organization (WHO) pointing to the over 118000 cases of Coronavirus disease 2019 (COVID- 19) in over 110 countries. Despite the promising results of drug repositioning studies in the treatment of COVID-19, the evidence of their safety and efficacy remains inconclusive. Cell based therapy has been proven safe and possibly effective in treating multiple lung injuries and diseases but its potential use in the treatment of COVID-19 has not been yet elucidated. Our aim in this review is to provide an overview on the immunomodulatory effect and the regenerative capacity of stem cells and their secretome in the treatment of many diseases including lung injuries. Those findings may contribute to a better understanding of the potential of stem cell therapy in SARS-CoV-2 infection and its potential use in order to find a solution for this healthcare crisis.

Keywords:

Coronavirus, COVID-19, stem cells, cytokine storm, lung injuries.

Affiliation:

Laboratoire d’Innovation Thérapeutique, “Stem cell, Organogenesis and Regenerative Medicine” Master Program - Lebanese University, Faculty of sciences, Laboratoire d’Innovation Thérapeutique, “Stem cell, Organogenesis and Regenerative Medicine” Master Program - Lebanese University, Faculty of sciences, Department of Anatomy, Cell Biology and Physiological Sciences, Faculty of Medicine, American University of Beirut, Beirut, Laboratoire d’Innovation Thérapeutique, Departments of Biology – Chemistry and Biochemistry, Lebanese University, Faculty of sciences II, Fanar, Laboratoire d’Innovation Thérapeutique, Departments of Biology – Chemistry and Biochemistry, Lebanese University, Faculty of sciences II, Fanar



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