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Studying Adsorption and Cellular Toxicity of Boron Nitride Nanostructure versus Melphalan Anti-ovarian Cancer Drug

Author(s):

Min Fu, Reza Tayebee*, Satar Saberi, Narjes Nourbakhsh, Effat Esmaeili, Behrooz Maleki and Hamid R. Vatanpour  

Abstract:


Background: Inclusion of anticancer drugs into biocompatible nanoparticulate carriers decreases the general toxicity and improves the efficacy of clinical treatments due to the reduction of soluble circulating free drug.

Methods: In addition, removal of emerging drug contaminants from wastewaters is a necessity that should be seriously attended. Boron nitride (BN) is choice in drug delivery because of many surprising properties. Here, boron nitride nanoparticles are prepared, characterized by Fourier-transform infrared spectroscopy (FT-IR) and x-ray diffraction (XRD) and used in the delivery of melphalan anti-cancer drug.

Results: Then, density functional theory (DFT) calculations are carried out to study adsorption of this drug on the surface of pure boron nitride fullerene via familiar hybrid functionals B3LYP and B3PW91. In addition, the polarizable continuum model (PCM) calculations show that BN is stable in water.

Conclusion: Finally, the in vitro cellular toxicity and viability of BN nanoparticles was examined on ES-2 cancer cells. The inhibitory dose IC50 of the material confirmed an acceptable cytotoxicity and nanoparticles affected the average growth of ES-2 cancer cells.

Keywords:

Melphalan, adsorption, DFT method, boron nitride fullerene, anti-ovarian cancer drug

Affiliation:

Department of Pharmacy Intravenous Admixture Services, Weifang People's Hospital, Weifang City, Shandong Province, Department of Chemistry, School of Sciences, Hakim Sabzevari University, Sabzevar, 96179 -76487, Department of Basic Sciences, Farhangian University, Tehran, Department of Chemistry, School of Sciences, Hakim Sabzevari University, Sabzevar, 96179 -76487, Department of Chemistry, Payame Noor University (PNU), Tehran, 19395‐ 4697, Department of Chemistry, School of Sciences, Hakim Sabzevari University, Sabzevar, 96179 -76487, Department of Basic Sciences, Farhangian University, Tehran



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