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Cell-adhesion molecules as key mechanisms of tumor invasion: the case of breast cancer

Author(s):

Carla Luís, Raquel Soares, Rúben Fernandes and Mónica Botelho*  

Abstract:


Cancer is a major health problem worldwide and the second leading cause of death only overcome by cardiovascular diseases. Breast cancer is the leading cause of mortality and morbidity among women and one of the most common malignant neoplasms prompt to metastatic disease. In the present review, the mechanisms of the major cell adhesion molecules involved in tumor invasion are discussed, focusing in the case of breast cancer. A non-systematic updated revision of the literature was performed in order to assemble information regarding the expression of the adhesion cell molecules associated with metastasis.

Keywords:

Breast cancer, Metastasis, Cell Adhesion Molecules, Cadherins, Selectins, Integrins, IgCAM

Affiliation:

Department of biomedicine, faculty of medicine, university of Porto, Porto, Department of biomedicine, faculty of medicine, university of Porto, Porto, Polytechnic Institute of Porto, Porto, National Health Institute Ricardo Jorge, Porto



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