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Ketogenic diet: A promising neuroprotective composition for managing Alzheimer’s diseases and its pathological mechanisms


Badrinathan Sridharan and Meng-Jen Lee*  


Ketogenic diet and ketone bodies gained significant attention in recent years due to their ability to influence the specific energy metabolism and restoration of mitochondrial homeostasis that can help in hindering the progression of many metabolic diseases including diabetes and neurodegenerative diseases. Ketogenic diet consists of high fat and low carbohydrate contents which makes the body glucose deprived and rely on alternative sources (ketone bodies) for energy. It has been initially designed and supplemented for the treatment of epilepsy and later its influence on many energy-deriving biochemical pathways made it a highly sorted food supplement for many metabolic diseases and even by healthy individuals for body building and calorie restriction. Among the reported therapeutic action over a range of diseases, neurodegenerative disorders especially Alzheimer’s disease gained the attention of many researchers and clinicians because of its potency and its easier supplementation as a food additive. Complex pathology and multiple influencing factors of Alzheimer’s disease make exploration of its therapeutic strategies a demanding task. It was a common phenomenon that energy deprivation in neurological disorders including Alzheimer’s disease, to progress rapidly. The ability of ketone bodies to stabilize the mitochondrial energy metabolism makes it a suitable intervening agent. In this review, we will discuss various research progress made with regards to ketone bodies/ketogenic diet for management of Alzheimer’s disease and elaborate in detail about the mechanisms that are influenced during their therapeutic action.


Ketogenic diet, neurodegenerative disorders, Alzheimer's disease, metabolic diseases, β-hydroxybutyrate (BHB), endothelial dysfunction


Department of Applied Chemistry, Chaoyang University of Technology, 168 Jifeng East Road, Taichung, Department of Applied Chemistry, Chaoyang University of Technology, 168 Jifeng East Road, Taichung

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