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LncRNAs roles in Chemoresistance of Cancer cells

Author(s):

Sina Taghvimi, Sepideh Abbaszadeh, Fatemeh Bahrami Banan, Elahe Soltani Fard, Zeinab Jamali, Milad Ahmadi Najafabadi, Amir Savardashtaki and Ahmad Movahedpour*  

Abstract:


Cancer is an important health issue worldwide. Cancer therapy is multifaceted, and drug resistance is still the major limiting factor in treatment of patients with this disease. Although the mechanisms of anticancer drug resistance have been broadly investigated, a massive biological signal pathway of Non-coding RNAs (ncRNAs) involved in this process has not been completely understood. Long noncoding RNAs (lncRNAs) are a kind of transcripts with a minimum length of 200 nucleotides in size which have a limited potential for coding proteins. The roles of these RNA molecules have been evaluated in relation to several pathological processes including tumor formation and progression. Increasing evidence haverecently reported that non-coding RNAs (ncRNAs), particularly long non-coding RNAs have significant roles in many cellular and genomic processes, and because of their potential in regulation specific genes, they are also involved in drug resistance. In this review, we review the literature on the features oflncRNA, their regulation roles in the gene expression related to chemoresistance and the potential of these RNAs as targeted therapies for personalized treatment in cancers.

Keywords:

Non-coding RNAs, Long non-coding RNAs , Drug resistance, personalized treatment, cancer, epithelial to mesenchymal transition

Affiliation:

Shahid Chamran University of Ahvaz, Biology, Ahvaz, Molecular Medicine and Genetics, Hamadan University of Medical Sciences, Hamdan, Molecular Medicine and Genetics, Hamadan University of Medical Sciences, Hamdan, Molecular Medicine, Shahrekord University of Medical Sciences, Shahrekord, Medical Genetics, Tehran University of Medical Sciences, Tehran, Medical Biotechnology, Tarbiat Modares University, Tehran , Medical Biotechnology, Shiraz University of Medical Sciences, Shiraz, Medical Biotechnology, Shiraz University of Medical Sciences, Shiraz



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