Robert Patejdl and Uwe K. Zettl Pages 4443 - 4452 ( 10 )
Animal models have been used widely in neurology since many decades. They have led to an improved understanding of the pathophysiological processes underlying frequent diseases as multiple sclerosis or Parkinson’s disease and enabled the development of highly effective therapeutical approaches. Current developments, drawbacks and limitations of animal models in neurology are discussed with a special focus on the experimental autoimmune encephalomyelitis – model of multiple sclerosis.
Animal models, neurology, multiple sclerosis, encephalitogenic epitopes, experimental autoimmune encephalomyelitis, microarray, transgene animals, natalizumab, Parkinson’s disease, conditioned reflex.
Department of Neurology, University of Rostock, Gehlsheimer Str. 20, 18147 Rostock, Germany.