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Anticancer Activity and DNA Binding of 4-Alkylenediamines Modified Naphthalimide Derivatives

[ Vol. 11 , Issue. 6 ]

Author(s):

Ke-Rang Wang, Feng Qian, Zi-Bo Yang, Hong-Wei An, Dan Han, Hua Chen, Ping-Zhu Zhang and Xiao-Liu Li   Pages 742 - 748 ( 7 )

Abstract:


Four naphthalimide derivatives 2-5 modified with various alkylenediamines at 4-position have been designed and synthesized. Their anticancer activities were preliminarily evaluated, which showed potent anticancer activities against A549 cell line with IC<sub>50</sub> values lower than 5 &#181;M. Furthermore, the DNA binding properties of 2 with calf thymus (Ct) DNA were investigated by UV-Vis, fluorescence, and circular dichroism (CD) spectroscopies and thermal denaturation experiment. The results showed that compound 2 as the DNA intercalator exhibited strong binding affinity with Ct- DNA.

Keywords:

Naphthalimide, DNA intercalator, Alkylenediamines, Anticancer, DNA binding, Fluorescence.

Affiliation:

, , , , , , , Key Laboratory of Chemical Biology of Hebei Province, College of Chemistry and Environmental Science, Hebei University, Baoding 071002, China.

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