Victoria Benson, Aisling Clare McMahon and Harry Claude Lowe Pages 219 - 227 ( 9 )
Current treatments for AMI centre on prompt restoration of epicardial coronary blood flow. Despite improvements, AMI is still associated with significant morbidity and mortality. Novel approaches are therefore keenly sought. Intercellular adhesion molecule-1 (ICAM-1, CD54) is a member of the immunoglobulin superfamily. It is implicated in neutrophil and monocyte-endothelial cell adhesion, processes contributing to myocardial neutrophil infiltration and microvascular coronary slow flow, both viewed as important to the pathophysiologic responses in AMI. ICAM-1 would therefore appear an important potential therapeutic target in this context, and is the subject of this review.
Acute myocardial infarction, ischaemia, reperfusion, adhesion molecule
Vascular Biology Laboratory, Concord Repatriation General Hospital, Hospital Rd,Concord NSW 2139, Australia.