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Ultrasound-promoted One-pot Synthesis of 2-Thioxo-dihydropyrimidine Derivatives Bearing Piperidinylamide Moiety

[ Vol. 11 , Issue. 9 ]


Bao-Hua Chen, Ji-Tai Li, Rui-Jia Lan and Guo-Feng Chen   Pages 643 - 650 ( 8 )


A convenient and efficient one-pot synthesis of 2-thioxo-dihydropyrimidine derivatives bearing piperidinylamide moiety is described. The reactions were carried out in 81-91% yields via the condensation of 1-(piperidin-1- yl)butane-1,3-dione with aromatic aldehyde and thiourea in ethanol catalyzed by p-toluenesulfonic acid at room temperature under ultrasound irradiation. The advantages of this methodology are convenient operation, mild conditions, short reaction times and high yields.


Catalysis, condensation, one-pot synthesis, piperidinylamide, 2-thioxo-dihydropyrimidine, ultrasound irradiation.


, , , College of Chemistry and Environmental Science, Hebei University, Wusi East Road No.180, Baoding 071002, P.R. China.

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