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Endogenous Inhibitors of HIV: Potent Anti-HIV Activity of Leukemia Inhibitory Factor

[ Vol. 2 , Issue. 8 ]

Author(s):

B. K. Patterson, A. Tjernlund and J. Andersson   Pages 713 - 722 ( 10 )

Abstract:


The correlates of protective immunity in HIV-1 infection include the endogenous production of compounds with anti-HIV-1 activity. These compounds can be produced independently of specific humoral or cellular immune responses. A model of compartmental inhibition of HIV-1 infection is the placenta, an organ that prevents transmission of HIV-1 to the fetus in the majority of HIV-1 pregnancies. Studies of this organ elucidated new compounds and mechanisms for prevention and treatment of HIV including the potent inhibitor of HIV-1, leukemia inhibitory factor (LIF). Besides coordinating the humoral and cellular immune responses, cytokines such as IFN-? exhibit intrinsic antiviral activity that represents the first line of defense against pathogens prior to the development of a specific immune response. The study of antiviral factors is particularly important in HIV / AIDS because of the direct destruction of the immune system by HIV-1. In this report, we focus on the identification and mechanism of endogenously produced anti-HIV factors and the overall function of these factors in the prevention and treatment of HIV / AIDS.

Keywords:

hiv, lif, cytokines, jak, stat, reverse transcription, transcription, placenta

Affiliation:

Department of Pediatrics, Division of Infectious Diseases, Childrens Memorial Hospital, Northwestern University Medical School, 2300 Childrens Plaza no.51, Chicago, IL 60614, USA



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