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New Missions for an Old Agent: Granulocyte-Colony Stimulating Factor in the Treatment of Stroke Patients

[ Vol. 22 , Issue. 10 ]

Author(s):

Ihsan Solaroglu, Murat Digicaylioglu, G. Evren Keles and John H. Zhang   Pages 1302 - 1309 ( 8 )

Abstract:


Granulocyte-colony stimulating factor (G-CSF) has a multimodal neuroprotective profile and the cumulative preclinical data from numerous translational studies statistically confirmed the efficacy of G-CSF as a treatment option in ischemic stroke. G-CSF activates anti-apoptotic, antioxidative, and anti-inflammatory signaling pathways and stimulates angiogenesis and neurogenesis. In this review, we summarize the role of G-CSF and the corresponding signal transduction pathways regulated by G-CSF in neuroprotection and discuss its potential as a new drug for stroke treatment.

Keywords:

Granulocyte-colony stimulating factor, neuroprotection, stroke, treatment.

Affiliation:

Koc University, School of Medicine, Department of Neurosurgery, Rumelifeneri Yolu, Sariyer 34450, Istanbul, Turkey.



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