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Serotonin 5-HT<sub>1A</sub> Receptors and Antipsychotics - An Update in Light of New Concepts and Drugs

[ Vol. 21 , Issue. 26 ]


Andrew C. McCreary and Adrian Newman-Tancredi   Pages 3725 - 3731 ( 7 )


Schizophrenia is characterised by positive, negative, cognitive, depressive and anxiety symptoms. Over the last decades a number of novel treatment strategies with better clinical efficacy and scope, but with lower side-effect profiles have been developed. These have significantly improved the management and prognosis of the disease. Of these approaches, modulation of the serotonergic receptor system is a common, recurring, theme; particularly the use of 5-HT<sub>1A</sub> receptor agonism as part of or adjunct to existing therapies. Here we review data exploring the utility of 5-HT<sub>1A</sub> receptor agonists for extending the actions of antipsychotic agents, while limiting their side-effect profile. Notably, interest has grown concerning 5-HT<sub>1A</sub> receptor activation in schizophrenia because of the development of novel antipsychotics, such as lurasidone and cariprazine, the characterisation of 5-HT<sub>1A</sub> receptor polymorphisms in schizophrenia patients and the possible beneficial influence of 5-HT<sub>1A</sub> agonists on neurogenesis.


Schizophrenia, 5-HT<sub>1A</sub>, negative symptoms, cognitive symptoms, psychosis, clinical, non-clinical.


Brains On-Line, de Mudden 16, 9747AW Groningen, The Netherlands.

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