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The Role of PEDF in Tumor Growth and Metastasis

[ Vol. 10 , Issue. 3 ]

Author(s):

D. Hoshina, R. Abe, S.-I. Yamagishi and H. Shimizu   Pages 292 - 295 ( 4 )

Abstract:


Pigment epithelium-derived factor (PEDF), one of the non-inhibitory serpines, is widely expressed throughout the body. Although PEDF was initially identified as a neuronal differentiation factor, more attention has been paid to its anti-angiogenic activity. Additionally, recent researches have demonstrated that PEDF has an anti-tumor effect against several human neoplasms. This review focuses on the pathological role of PEDF in tumors, especially tumor growth and metastasis. PEDF is an endogenous anti-tumor factor and its clinical application seems quite promising, although there is much to be further investigated.

Keywords:

PEDF, tumor, growth, metastasis

Affiliation:

Department of Dermatology, Hokkaido University Graduate School of Medicine, North 15 West 7, Kita-ku, Sapporo 060-8638, Japan.



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