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E2F1 and NF-κB: Key Mediators of Inflammation-associated Cancers and Potential Therapeutic Targets

[ Vol. 16 , Issue. 9 ]

Author(s):

Yulin Huang, Rui Chen and Jianwei Zhou   Pages 765 - 772 ( 8 )

Abstract:


Inflammation is the fundamental protective response; however disordered immuno-response can cause chronic human disease, including cancer. Inflammatory cells and mediators are essential to the tumor microenvironment and dissection of this complex molecular and cellular milieu may elucidate a connection between cancer and inflammation and help to identify potential novel therapeutic targets. Thus, focusing on transcription factor NF-κB and E2F1 in inflammation-associated cancer is urgent. NF-κB activation is prevalent in carcinomas, mainly driven by inflammatory cytokines in the tumor microenvironment. E2F1 is also involved in regulating immune responses. Understanding the crosstalk between the two pathways may contribute to the development of novel anti-cancer drugs.

Keywords:

Inflammation associated cancer, NF-κB, E2F1, therapeutic target.

Affiliation:

, Key Laboratory of Environmental Medicine Engineering, Ministry of Education, School of Public Health, Southeast University, Dingjiaqiao 87, Nanjing, 210009, P.R. China., Department of Molecular Cell Biology and Toxicology, School of Public Health, Nanjing Medical University, 101Longmian Avenue, Nanjing 211166, People’s Republic of China.

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