Narges Dastmalchi, Reza Safaralizadeh* and Shahram Teimourian Pages 851 - 859 ( 9 )
Colorectal cancer (CRC) is one of the main causes of malignancy-related mortality worldwide. It was well-identified that microRNAs (miRNAs) decisively participate in cellular biological pathways; in a way that their deregulated expression causes CRC progression. miRNAs can control the translation and degradation of mRNAs by binding to various molecular targets involved in different biological processes, including growth, apoptosis, cell cycle, autophagy, angiogenesis, metastasis, etc. The functions of these dysregulated miRNAs may be either oncogenic or tumorsuppressive. Therefore, these miRNAs can be contributed to prognostic, diagnostic, and therapeutic approaches in CRC. In this study, we reviewed the tumor-suppressive and oncogenic functions of miRNAs in CRC and assessed their molecular activities in CRC development. However, further investigation for the involvement of dysregulated miRNAs in CRC progression is required.
Colorectal cancer, MicroRNA, molecular function, biological pathways, chemotherapy, resveratrol.
Department of Animal Biology, Faculty of Natural Sciences, University of Tabriz, Tabriz, Department of Animal Biology, Faculty of Natural Sciences, University of Tabriz, Tabriz, Department of Medical Genetics, School of medicine, Iran University of Medical Sciences (IUMS), Tehran