Submit Manuscript  

Article Details


Caveolin-1 in Cell Migration and Metastasis

[ Vol. 14 , Issue. 2 ]

Author(s):

S. Nunez-Wehinger, R.J. Ortiz, N. Diaz, J. Diaz, L. Lobos-Gonzalez and A.F.G. Quest   Pages 255 - 274 ( 20 )

Abstract:


Caveolin-1 is a member of the caveolin family that has been ascribed a dual role in cancer. In early stages of disease the protein functions predominantly as a tumor suppressor, whereas at later stages, caveolin-1 expression is associated with tumor progression and metastasis. Here, some mechanisms associated with caveolin-1-dependent tumor suppression will be briefly discussed before focusing on the role of this protein and particularly phosphorylation of tyrosine-14 in promoting cell migration, invasion and metastasis. Models are provided summarizing possible explanations for these dramatic changes in function, as well as mechanisms by which this may be achieved.

Keywords:

Cancer progression, Caveolin-1 (CAV1), invasion, metastasis, migration, phosphorylation, tyrosine-14.

Affiliation:

Independencia 1027, Facultad de Medicina, Universidad de Chile, Santiago, Chile.



Read Full-Text article