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Regulation of Eye Development by Protein Serine/Threonine Phosphatases-1 and -2A

[ Vol. 15 , Issue. 10 ]

Author(s):

L. Wang, Y. Yang, X. -D. Gong, Z. -X. Huang, Q. Nie, Z. -F. Wang, W. -K. Ji, X. -H. Hu, W. -F. Hu, L. -L. Gong, L. Zhang, S. Huang, R. -L. Qi, T. -H. Yang, Z. -G. Chen, W. -B. Liu, Y. -Z. Liu and D. W. -C. Li   Pages 944 - 951 ( 8 )

Abstract:


The protein serine/threonine phosphatases-1 and -2A are major cellular phosphatases, playing a fundamental role in organisms from prokaryotes to eukaryotes. They contribute to 90% dephosphorylation in eukaryote proteins. In the eye, both phosphatases are highly expressed and display important functions in regulating normal eye development. Moreover, they are implicated in pathogenesis through modulation of stress-induced apoptosis. Here we review the recent progresses on these aspects.

Keywords:

Serine/threonine phosphatases-1 and -2A, eye development, lens differentiation, developmental apoptosis.

Affiliation:

Key Laboratory of Protein Chemistry and Developmental Biology of Educational Ministry of China, College of Life Sciences, Hunan Normal University, Changsha, Hunan 410081, China.



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