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Sumoylation in Lens Differentiation and Pathogenesis

[ Vol. 16 , Issue. 10 ]


J.-W. Xiang, Z.-G. Chen, L. Gong, Y. Xiao, W.-J. Qing, L. Wang, X.-H. Hu, Z.-X. Huang, R.-L. Qi, T.-H. Yang, A.-P. Arrigo, L. Zhang, X.-C. Tang, S. Huang, F.-Y. Liu, Z.-W. Luo, Y.-F. Liu, Q. Sun, J. Gigantelli, Y.-Z. Liu and D. W.-C. Li   Pages 859 - 870 ( 12 )


Sumoylation, a post-translational modification discovered over a decade ago, turns out to be a very important regulatory mechanism mediating multiple cellular processes. Recent studies from our laboratory and others also revealed that it plays a crucial role in regulating both differentiation and pathogenesis of the ocular lens. This review will summarize these progresses.


Lens, sumoylation, differentiation, cataractogenesis, pathogenesis.


Key Laboratory of Protein Chemistry and Developmental Biology of Educational Ministry of China, College of Life Sciences, Hunan Normal University, Changsha, Hunan 410081

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