Dineshi Sewvandi Thalakiriyawa , Primali Rukmal Jayasooriya and Waruna Lakmal Dissanayaka*
Mesenchymal stem cells (MSCs) are considered multipotent cells that can differentiate into diverse cell lineages. MSCs based therapy has become a widely experimented treatment strategy in regenerative medicine with promising outcomes. Recent reports suggest that much of the therapeutic effects of MSCs are mediated by their secretome that is expressed through extracellular vesicles (EVs). EVs are lipid bilayer bound components that cargo cellular proteins, mRNA, lncRNAs and other molecules in order to mediate intercellular communication and signaling. In fact, MSC derived EVs have been observed to implement the same therapeutic effects as MSCs with minimal adverse effects and could be used as an alternative treatment method to MSC based therapy. The regenerative activity of MSC-EVs has been observed in relation to multiple cell/tissue lineages using various animal models. However, further research and clinical trials are essential for the advancement of this novel treatment strategy. This review provides an insight into the available literature on applications of MSC-EVs in relation to angiogenesis, neurogenesis, hepatic and kidney regeneration and wound healing.
Extracellular vesicles, Mesenchymal stem cells, Regenerative medicine, Secretome, Paracrine signaling, Regeneration
Department of Oral Medicine and Periodontology, Faculty of Dental Sciences, University of Peradeniya, Peradeniya, Department of Oral Medicine and Periodontology, Faculty of Dental Sciences, University of Peradeniya, Peradeniya, Department of Oral Pathology, Faculty of Dental Sciences, University of Peradeniya, Peradeniya