The recent developments in the field of extracellular vesicles (EVs) point to their potential use for predicting and treating neurodegenerative diseases. This reviews focusses on the importance and latest advances in this field especially with respect to Alzheimer’s disease (AD). Increasing evidence show that progression of amyloid-beta and tau brain pathology is correlated to the cognitive decline associated with AD. Lot of experimental data suggests involvement of EVs with these processes for instance EVs are known to circulate the misfolded proteins involved in AD. The currently available information on role of EVs in neurodegenerative disorder especially in AD and have also presented the knowledge gaps on which future research efforts should be focused.
Extracellular vesicles, Alzheimer’s disease, Neurodegeneration, Exosomes, Aβ aggregation, biomarkers
Department of Chemistry, Miranda House, University of Delhi