Submit Manuscript  

Article Details

The Control of Endoplasmic Reticulum-Initiated Apoptosis by the BCL-2 Family of Proteins

[ Vol. 6 , Issue. 1 ]


Scott A. Oakes, Stephen S. Lin and Michael C. Bassik   Pages 99 - 109 ( 11 )


Irreversible perturbations in the homeostasis of the endoplasmic reticulum (ER) are thought to lead to apoptosis and cell loss in a number of important human diseases, including Alzheimer disease, Parkinson disease, and type 2 diabetes. However, the exact mechanisms that lead from ER stress to cell death remain incompletely understood. Recent work has shown that the BCL-2 family of proteins plays a central role in regulating this form of cell death, both locally at the ER and from a distance at the mitochondrial membrane.


BH4-domain, mitochondrion, Homeostasis, Cell Death, IP3 Receptor, transcription factor, NOXA expression


Department of Pathology, University of California, San Francisco, CA 94143, USA.

Read Full-Text article