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Escape Mutations in HIV Infection and its Impact on CD8+ T Cell Responses

[ Vol. 7 , Issue. 5 ]


Mariola Lopez, Vincent Soriano and Jose Miguel Benito   Pages 446 - 458 ( 13 )


Cellular immune responses play an important role in the control of HIV replication. Although clear evidence exists on its influence during acute HIV infection, its role during the chronic phase of the disease remains controversial. This review describes the cellular immune responses elicited against HIV mediated by CD8+ T lymphocytes, and the mechanisms by which these cells are inefficient to completely control HIV replication and halt disease progression. The role of escape mutations as one of the most relevant mechanisms HIV has developed to evade host cellular immune responses is highlighted.


HIV-1, CTL, immune response, immune escape


Department of Infectious Diseases, Hospital Carlos III, C/ Sinesio Delgado, 10, 28029 Madrid,Spain.

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