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Molecular Basis of IgA Nephropathy

[ Vol. 5 , Issue. 5 ]


Andrew S.H. Lai and Kar Neng Lai   Pages 475 - 487 ( 13 )


IgA nephropathy (IgAN) is the most common glomerulonephritis worldwide and remains an important cause of end-stage renal failure. However, the basic molecular mechanism(s) underlying abnormal IgA synthesis, selective mesangial deposition with ensuing mesangial cell proliferation and extracellular matrix expansion remains poorly understood. Notably, the severity of tubulointerstitial lesions better predicts the renal progression than the degree of glomerular lesions. The task of elucidating the molecular basis of IgAN is made especially challenging by the fact that both environmental and genetic components likely contribute to the development and progression of IgAN. This review will summarize the earlier works on the structure of the IgA molecule, mechanisms of mesangial IgA deposition and pathophysiologic effects of IgA on mesangial cells following mesangial deposition. Recently, a series of important advances in the area of communication between the glomerular mesangium and renal tubular cells have emerged. These novel findings regarding the molecular pathogenesis of IgAN will be helpful in designing future directions for therapy.


Iga nephropathy, Iga, mesangial inflammation, tubulointerstitial injury, electrostatic charge, growth factors, renin-angiotensin system, angiotensin II receptors


Department of Medicine, University of Hong Kong, Room 409, Professorial Block, Queen MaryHospital, 102, Pokfulam Road, Hong Kong.

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