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Mucosa-Associated Lymphoid Tissues in the Aerodigestive Tract: Their Shared and Divergent Traits and Their Importance to the Orchestration of the Mucosal Immune System

[ Vol. 5 , Issue. 6 ]


Jun Kunisawa, Satoshi Fukuyama and Hiroshi Kiyono   Pages 557 - 572 ( 16 )


As inductive tissues for the initiation of antigen-specific T and B cell responses, the various mucosa-associated lymphoid tissues (MALT) of the aerodigestive tract, which include gut-associated lymphoid tissue (GALT), nasopharynx-associated lymphoid tissue (NALT) and bronchus-associated lymphoid tissue (BALT), share many histological and immunological characteristics. However, recent advances in our molecular and cellular understanding of immunological development have revealed that the various types of MALT also exhibit different molecular and cellular interactions for their organogenesis. In this review, we delineate the distinctive features of GALT, NALT and BALT and seek to show the role played by those features in the regulation of mucosal tissue organogenesis, the mucosal immune system, and mucosal homeostasis, all in an attempt to provide insights which might lead to a prospective mucosal vaccine.


gut-associated lymphoid tissue, nasopharynx-associated lymphoid tissue, bronchus-associated lymphoid tissue, peyers patches, isolated lymphoid follicles, dendritic cells, tumor necrosis factor, epithelial cells, organogenesis, mucosal vaccine


Division of Mucosal Immunology, Department of Microbiology and Immunology, The Instituteof Medical Science, The University of Tokyo, 4-6-1 Shirokanedai, Minato-ku, Tokyo 108-8639, Japan.

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