Berran Yucesoy, Michael L. Kashon and Michael I. Luster Pages 39 - 48 ( 10 )
Genes which encode inflammatory cytokines are subject to polymorphisms in their regulatory regions that may effect both the level and ratio of cytokines produced in response to exogenous stimuli. These variant alleles are observed in a large percent of the population and are often associated with increased or decreased susceptibility or severity (modifiers) to infectious, immune or inflammatory diseases. Environmental factors can also play either a direct (i.e., causative factor) or indirect (modifying factor) role in these diseases. Thus, it would follow that gene-environment interactions would effect the expression and / or progression of the disease. In the present review, the concept that some of the common allelic variants found in cytokine genes represent modifying factors in chronic inflammatory diseases associated with occupational exposure is discussed.
single nucleotide polymorphisms, cytokine network, chronic inflammatory diseases, occupational diseases, cytokine polymorphisms
Toxicology and Molecular Biology Branch, Health Effects Laboratory Division, National Institute forOccupational Safety and Health, 1095 Willowdale Road, Morgantown,West Virginia 26505, USA