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Molecular Steps of Tumor Necrosis Factor Receptor-Mediated Apoptosis

[ Vol. 1 , Issue. 3 ]

Author(s):

S. Gupta   Pages 317 - 324 ( 8 )

Abstract:


Until recently it was believed that TNF-induced apoptosis is mediated exclusively by TNF-RI because TNF-RII lacks death domain. However, it has been demonstrated that TNF-RII enhances TNF-RI-mediated apoptosis. In this review, I have discussed the evidence and mechanisms by which TNF-RII regulates TNF-alpha-induced apoptosis. A role of RIP is emphasized and novel mechanisms of FLIP-mediated inhibition of apoptosis are discussed. In addition, various mechanisms of TNF-induced activation of mitochondrial pathway of apoptosis have been reviewed.

Keywords:

Tumor Necrosis Factor, Receptor-Mediated Apoptosis, Tumor necrosis factor (TNF-a), TNFRI, TRADD (TNF receptor-associated death-domain), TRAF-2, MAP kinase, NFkB

Affiliation:

Medical Sciences I, C-240, University of California, Irvine, CA 92697, USA



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